反应详情

To a solution of N-(2-phenylethyl)-4-[4-(trifluoromethyl)phenyl]-1,3-thiazole-2-amine (500 mg, 1.43 mmol) in N,N-dimethylformamide (5 mL) was added sodium hydride (50 mg, in oil, 1.3 mmol) at room temperature, and the mixture was stirred at room temperature for 1 hr. Ethyl 3-(4-{[4-(chloromethyl)benzyl]oxy}-2-fluorophenyl)propanoate (350 mg, 1.0 mmol) was added, and the mixture was further stirred at room temperature for 2 hr. The reaction mixture was poured into 1N hydrochloric acid, and the mixture was extracted with ethyl acetate. The organic layer was concentrated. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:19-3:2 in volume ratio) to give the title compound as a yellow oil.

1. stirringthe mixture was further stirred at room temperature for 2 hr
2. extractionthe mixture was extracted with ethyl acetate
3. concentrationThe organic layer was concentrated
4. customThe residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:19-3:2 in volume ratio)