Hydrochloric Acid → HCID 2959610, compound

HRID 732666Notes

Reaction equation

HRID 732666 reaction equation
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7][NH2:8])=[CH:5][CH:4]=1.[C:11]([OH:19])(=[O:18])[C:12]([CH2:14][C:15](O)=[O:16])=[CH2:13].Cl>>[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7][N:8]2[C:15](=[O:16])[CH2:14][CH:12]([C:11]([OH:19])=[O:18])[CH2:13]2)=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 811Itaconic acidHCID 754524-Methoxybenzylamine

Product 1

HCID 2959610HCID 2959610, compound

Procedure

4-Methoxybenzylamine was added to an aqueous solution of itaconic acid and heated under reflux for 12Hours. After completion of the reaction, this was cooled in an ice bath and mixed with 1 M hydrochloric acid, and the thus precipitated crystals were collected by filtration to obtain 1-(4-methoxybenzyl)-5-oxopyrrolidine-3-carboxylic acid as colorless crystals. EP: 250.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 12Hours
  3. customAfter completion of the reaction
  4. temperaturethis was cooled in an ice bath
  5. filtrationthe thus precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-1a686b8204534570867e0f2d822cb5a6
Source dataset
uspto-grants-2009_09
Patent number
US07585886B2

Reaction notes

Loading…