反应详情

To a solution of 7-chloro-1H-pyrrolo[2,3-c]pyridine-4-carboxylic acid (110 mg) in dimethylformamide (4 ml) was added 4-ethylmorpholine (187 μl), tetrahydro-pyran-4-ylmethylamine (97 mg), 1-hydroxybenzotriazole hydrate (118 mg) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (129 mg) and the solution stirred at room temperature overnight. The dimethylformamide was evaporated and the residue dissolved in ethyl acetate (10 ml). The organic layer was then washed with 5% sodium hydrogen carbonate solution (4 ml) and brine (4 ml). The organic layer was dried (MgSO4) and evaporated to give a pale orange solid. The solid was triturated with diethyl ether and then filtered off, sucked dry then dried at 40° C. under vacuum to afford the title compound (93 mg).

1. customThe dimethylformamide was evaporated
2. dissolutionthe residue dissolved in ethyl acetate (10 ml)
3. washThe organic layer was then washed with 5% sodium hydrogen carbonate solution (4 ml) and brine (4 ml)
4. dry with materialThe organic layer was dried (MgSO4)
5. customevaporated
6. customto give a pale orange solid
7. customThe solid was triturated with diethyl ether
8. filtrationfiltered off
9. customsucked dry
10. customthen dried at 40° C. under vacuum