Hydrochloric Acid → HCID 57843570, compound

HRID 734276Notes

Reaction equation

HRID 734276 reaction equation
C[O:2][C:3](=[O:26])[C:4]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=1)([CH3:17])[CH2:5][CH2:6][N:7]1[CH2:12][CH2:11][N:10]([S:13]([CH3:16])(=[O:15])=[O:14])[CH2:9][CH2:8]1.O[Li].O.Cl>O.C1COCC1>[Cl:25][C:20]1[CH:19]=[C:18]([C:4]([CH3:17])([CH2:5][CH2:6][N:7]2[CH2:8][CH2:9][N:10]([S:13]([CH3:16])(=[O:15])=[O:14])[CH2:11][CH2:12]2)[C:3]([OH:26])=[O:2])[CH:23]=[CH:22][C:21]=1[Cl:24]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 57843590HCID 57843590, compound

Product 1

HCID 57843570HCID 57843570, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 1.15 g (2.7 mmol) 2-(3,4-dichloro-phenyl)-4-(4-methanesulfonyl-piperazin-1-yl)-2-methyl-butyric acid methyl ester and 0.171 g (4.08 mmol) LiOH.H2O in 25 mL water and 25 mL THF was stirred at room temperature for 16 h. The mixture was treated with 4N HCl aq. and evaporated to dryness. The residue was used without further purification in the subsequent step. MS(m/e): 409.2 (MH+).

Workup

  1. customevaporated to dryness
  2. customThe residue was used without further purification in the subsequent step

Sources & evidence

ORD record
ord-32c47e8ebe544e3c9d01e1b4017c6422
Source dataset
uspto-grants-2009_09
Patent number
US07592345B2

Reaction notes

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