反应详情

温度

0 °C

(S)-Azetidine-2-carboxylic acid (250.4 mg, 2.5 mmol) was dissolved in DMF (15 mL) and distilled water (6 mL). The solution was cooled to 0° C., and DIEA (645 μL, 3.7 mmol) was added followed by benzyl chloroformate (530 μL, 3.7 mmol). The reaction was stirred at 0° C. and allowed to warm to ambient temperature overnight. The reaction was filtered and purified by reverse phase HPLC to give the desired product.

1. distillationdistilled water (6 mL)
2. temperatureto warm to ambient temperature overnight
3. filtrationThe reaction was filtered
4. custompurified by reverse phase HPLC