反应详情

温度

140 °C

DIPEA (4.89 mL, 28.0 mmol) was added to a solution of 5-bromo-6-chloro-N-(4-((trifluoromethyl)thio)phenyl)nicotinamide (Stage 11.2, 2.88 g, 7.0 mmol) and (S)-1-pyrrolidin-3-yl-methanol (1.156, 8.40 mmol) in iPrOH (7.0 mL) in a vial, which was sealed and then heated at 140° C. for 1 h. After cooling at RT, the RM was dissolved in EtOAc, washed with aq. 0.5 M HCl and brine, dried over Na2SO4 and the solvent was evaporated off under reduced pressure to give a residue which was triturated with iPr2O, filtered and dried to give the title compound as a beige crystalline powder. HPLC (Condition 4) tR=6.17 min, UPLC-MS (Condition 3) tR=1.20 min, m/z=476.2/478.2 [M+H]+.

1. customwas sealed
2. temperatureAfter cooling at RT
3. washwashed with aq. 0.5 M HCl and brine
4. dry with materialdried over Na2SO4
5. customthe solvent was evaporated off under reduced pressure
6. customto give a residue which
7. customwas triturated with iPr2O
8. filtrationfiltered
9. customdried