反应详情

2.37 g (10 mmol) of 5-coumalincarboxylic acid N-hydroxysuccinimide ester and a solution of 1.43 g (10 mmol) of 1-aminocyclohexanecarboxylic acid and 3.04 g (30 mmol) of triethylamine in 20 ml of dimethylformamide were stirred overnight. Ethyl acetate was added to the reaction solution, and the mixture was washed with a 10% aqueous potassium hydrogensulfate solution and then saturated brine. After it was dried with anhydrous sodium sulfate, the solvent was distilled off under reduced pressure to obtain 1.42 g (60%) of the title compound.

1. washthe mixture was washed with a 10% aqueous potassium hydrogensulfate solution
2. dry with materialAfter it was dried with anhydrous sodium sulfate
3. distillationthe solvent was distilled off under reduced pressure