Hydrochloric Acid → HCID 19423874, compound

HRID 743236Notes

Reaction equation

HRID 743236 reaction equation
[CH3:1][N:2]([CH3:25])[CH2:3][CH:4]([OH:24])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[CH2:13][CH2:14][CH:15]([CH3:23])[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[ClH:26]>C(OCC)(=O)C.O1CCOCC1>[ClH:26].[CH3:25][N:2]([CH3:1])[CH2:3][CH:4]([OH:24])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[CH2:13][CH2:14][CH:15]([CH3:23])[CH2:16][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

5

Reactant 2

HCID 313Hydrochloric Acid2×HCID 19423875HCID 19423875, compound

Product 1

HCID 19423874HCID 19423874, compound

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

Following a procedure similar to that described in Example 1(c), 987 mg of 3-dimethylamino-1-[2-(3-methyl-4phenylbutyl)phenoxy]-2-propanol [prepared as described in step (b) above] dissolved in 20 ml of ethyl acetate were converted to the hydrochloride by treating it with 0.9 ml of a 4N solution of hydrogen chloride in dioxane. The solvent was then removed by distillation under reduced pressure, and the resulting residue was dried in vacuo, to give 1.09 g (a quantitative yield) of the title compound as a colorless oil.

Workup

  1. customThe solvent was then removed by distillation under reduced pressure
  2. customthe resulting residue was dried in vacuo

Sources & evidence

ORD record
ord-56467583469e4e23b1dc63f0693b7f5a
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

Loading…