Hydrochloric Acid → HCID 57497639, compound

HRID 743314Notes

Reaction equation

HRID 743314 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][C:12]2[CH:26]=[CH:25][CH:24]=[CH:23][C:13]=2[O:14][CH2:15][C@H:16]2[O:21][CH2:20][CH2:19][N:18]([CH3:22])[CH2:17]2)[CH:7]=[CH:8][CH:9]=1>O1CCOCC1.C(OCC)(=O)C>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][C:12]2[CH:26]=[CH:25][CH:24]=[CH:23][C:13]=2[O:14][CH2:15][C@H:16]2[O:21][CH2:20][CH2:19][N:18]([CH3:22])[CH2:17]2)[CH:7]=[CH:8][CH:9]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22865497HCID 22865497, compound

Product 1

HCID 57497639HCID 57497639, compoundYield 91%

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

1 ml of a 4N solution of hydrogen chloride in dioxane was added to a solution of 1.04 g of (S)-2-{2-[2-(3-methoxyphenyl)ethyl]phenoxymethyl}-4-methylmorpholine [prepared as described in step (a) above] in 20 ml of ethyl acetate, and the resulting mixture was allowed to stand at room temperature. The crystals which precipitated were collected by filtration and dried in vacuo, to give 1.05 g (yield 91%) of the title compound as colorless crystals, melting at 186°-187° C.

Workup

  1. customto stand at room temperature
  2. customThe crystals which precipitated
  3. filtrationwere collected by filtration
  4. customdried in vacuo

Sources & evidence

ORD record
ord-ec4bd14488b24a97bcd6af52fa8e96bb
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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