3-Hydroxybenzaldehyde → 3-(Cycloheptylmethoxy)benzaldehyde

HRID 74332Notes

Reaction equation

HRID 74332 reaction equation
[CH:1]1([CH2:8][OH:9])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.O[C:30]1[CH:31]=[C:32]([CH:35]=[CH:36][CH:37]=1)[CH:33]=[O:34].N(C(OCC)=O)=NC(OCC)=O>C1COCC1>[CH:1]1([CH2:8][O:9][C:30]2[CH:31]=[C:32]([CH:35]=[CH:36][CH:37]=2)[CH:33]=[O:34])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

6

Reactant 4

HCID 1013-HydroxybenzaldehydeHCID 11776TriphenylphosphineHCID 78193CycloheptanemethanolHCID 220568ethyl N-ethoxycarbonyliminocarbamate

Product 1

HCID 866376133-(Cycloheptylmethoxy)benzaldehyde

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To an ice-cold solution of cycloheptylmethanol (5.244 g, 40.9 mmol), triphenylphosphine (10.73 g, 40.9 mmol) and 3-hydroxybenzaldehyde (11) (5.0 g, 40.9 mmol) in THF (50 mL) was added diethyl azodicarboxylate (9.097 g, 44.99 mmol). The reaction mixture was allowed to warm to room temperature and stirred overnight. The mixture was concentrated under reduced pressure, and the residue was suspended in 20% diethyl ether-hexanes. Solids were removed by filtration then the mixture was concentrated under reduced pressure. Purification by flash chromatography (5% EtOAc-hexanes) gave 3-(cycloheptylmethoxy)benzaldehyde as a colorless oil. Yield (3.9 g, 41%): 1H NMR (400 MHz, DMSO-d6) δ 9.95 (s, 1H), 7.46-7.51 (m, 2H), 7.39-7.40 (m, 1H), 7.25 (dt, J=6.8, 2.6 Hz, 1H), 3.81 (d, J=6.8 Hz, 2H), 1.88-1.93 (m, 1H), 1.76-1.82 (m, 2H), 1.22-1.68 (m, 10H).

Workup

  1. concentrationThe mixture was concentrated under reduced pressure
  2. customSolids were removed by filtration
  3. concentrationthe mixture was concentrated under reduced pressure
  4. customPurification by flash chromatography (5% EtOAc-hexanes)

Sources & evidence

ORD record
ord-57ce3f583c68444d89e8d6e38fc5fe4a
Source dataset
uspto-grants-2014_09
Patent number
US08829244B2

Reaction notes

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