Hydrochloric Acid → HCID 19423982, compound

HRID 743350Notes

Reaction equation

HRID 743350 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][C:10]1[CH:24]=[CH:23][CH:22]=[CH:21][C:11]=1[O:12][CH2:13][CH2:14][CH:15]1[CH2:19][CH2:18][CH2:17][N:16]1[CH3:20].[ClH:25]>C(OCC)(=O)C.O1CCOCC1>[ClH:25].[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][C:10]1[CH:24]=[CH:23][CH:22]=[CH:21][C:11]=1[O:12][CH2:13][CH2:14][CH:15]1[CH2:19][CH2:18][CH2:17][N:16]1[CH3:20]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19423983HCID 19423983, compound

Product 1

HCID 19423982HCID 19423982, compoundYield 84%

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

0.311 g of 2-(2-{2-[2-(2-fluorophenyl)ethyl]phenoxy}ethyl)-1-methylpyrrolidine [prepared as described in step (a) above] was dissolved in 10 ml of ethyl acetate, and 0.36 ml of a 4N solution of hydrogen chloride in dioxane was added to the solution. The mixture was then allowed to stand at room temperature, and the crystals which precipitated were collected by filtration and dried in vacuo, to give 0.290 g (yield 84%) of the title compound as colorless crystals, melting at 178°-180° C.

Workup

  1. customto stand at room temperature
  2. customthe crystals which precipitated
  3. filtrationwere collected by filtration
  4. customdried in vacuo

Sources & evidence

ORD record
ord-4ce084be5e1e46c2b08b4d5b8811d5d3
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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