反应详情

温度

0 °C

5-(2-Cyanophenyl)indole (2.3 mmole, 0.50 g) was dissolved in 3 ml THF, cooled to 0° C. Ethyl magnesium bromide (2.41 mmoles, 1.21 ml of 2.0M solution in ether) was added dropwise. Benzyl bromide (94.6 mole, 0.80 g) was added dropwise to the solution. The reaction was refluxed for 24 hours and poured into aqueous ammonium chloride and ethyl acetate. The organic phase was washed with water, dried over sodium sulfate, and concentrated. The intermediate was chromatographed over silica gel eluted with 10% ethyl acetate in hexane to yield 229 mg of 3-benzyl-5-(2-cyanophenyl)indole. (MS)

1. temperatureThe reaction was refluxed for 24 hours
2. washThe organic phase was washed with water
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated
5. customThe intermediate was chromatographed over silica gel
6. washeluted with 10% ethyl acetate in hexane