反应详情

[5-Amino-1-(2-methyl-1H-benzimidazol-5-yl)-1H-pyrazol-4-yl]-(1H-indol-2-yl)-methanone (194 mg) was dissolved in dimethylformamide (1.94 ml). An aqueous solution of 2 M hydrochloric acid (300 μl) was divided into five portions and separately added dropwise thereto at 25° C. 2-Propanol (4 ml) was divided into three portions and separately added to the reaction solution at five-minute intervals. The resulting precipitate was collected by filtration, and washed with 2-propanol (1 ml). Then, the powder was dried under reduced pressure at 40° C. This yielded an opalescent powder (188 mg, 88%).

1. additionseparately added dropwise
2. customat 25° C
3. additionseparately added to the reaction solution at five-minute intervals
4. filtrationThe resulting precipitate was collected by filtration
5. washwashed with 2-propanol (1 ml)
6. customThen, the powder was dried under reduced pressure at 40° C