Potassium Carbonate → HCID 15180155, compound

HRID 744662Notes

Reaction equation

HRID 744662 reaction equation
[SH2:1].[Na].Cl[C:4]1[C:5]([C:9]2[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=2)=[N:6][S:7][N:8]=1.C(=O)([O-])[O-].[K+].[K+].I[CH2:22][CH2:23][CH3:24]>CN(C=O)C.O>[CH2:22]([S:1][C:4]1[C:5]([C:9]2[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=2)=[N:6][S:7][N:8]=1)[CH2:23][CH3:24]

Participants

7

Reactant 4

HCID 11430Potassium CarbonateHCID 336431-IodopropaneHCID 104881643-Chloro-4-(pyridin-3-yl)-1,2,5-thiadiazoleHCID 86586439Sodium hydrogen sulphide

Product 1

HCID 15180155HCID 15180155, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

Sodium hydrogen sulfide (220 mg, 3 mmol) was added over 30 min. to a solution of 3-(4-chloro-1,2,5-thiadiazol-3yl)pyridine (0.59 g, 3 mmol) in DMF (20 ml) at room temperature. Potassium carbonate (1.24 g, 9 mmol) and iodopropan (0.76 g, 4.5 mmol) were added. The reaction mixture was stirred at room temperature for 30 min. Water was added and the mixture extracted with ether. The combined ether phases were dried and evaporated to give the title compound in 89% (0.63 g ) yield.

Workup

  1. extractionthe mixture extracted with ether
  2. dry with materialThe combined ether phases were dried
  3. customevaporated

Sources & evidence

ORD record
ord-6634d57d56d54fb19abb12cd8cc4b38c
Source dataset
uspto-grants-1996_09
Patent number
US05559138

Reaction notes

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