反应详情

Boc-Statine, 8.83 g., was dissolved in dry dimethylformamide and treated at 25° C. for 4.5 hours with 4.43 g. potassium carbonate and 3.81 ml. benzyl bromide. The mixture was concentrated in vacuo, 500 ml. ethyl acetate was added and the suspension was washed with saturated aqueous lithium chloride (2×50 ml.), water (5×50 ml.), dried magnesium sulfate, filtered and concentrated to give 11.8 g. of a yellow syrup which was used without further purification.

1. additiontreated at 25° C. for 4.5 hours with 4.43 g
2. concentrationThe mixture was concentrated in vacuo, 500 ml
3. additionethyl acetate was added
4. washthe suspension was washed with saturated aqueous lithium chloride (2×50 ml.), water (5×50 ml.), dried magnesium sulfate
5. filtrationfiltered
6. concentrationconcentrated
7. customto give 11.8 g
8. customof a yellow syrup which was used without further purification