Hydrochloric Acid → 2-Chloro-6-methanesulphonylamino-isonicotinic acid

HRID 74584Notes

Reaction equation

HRID 74584 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])[N:11]=1)[C:5]([O:7]C)=[O:6].[OH-].[Li+].Cl>O1CCCC1.O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])[N:11]=1)[C:5]([OH:7])=[O:6]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 86615008Methyl 2-chloro-6-methanesulphonylamino-isonicotinate

Product 1

HCID 866564982-Chloro-6-methanesulphonylamino-isonicotinic acid

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

0.29 g (1.1 mmol) methyl 2-chloro-6-methanesulphonylamino-isonicotinate in 5.0 mL tetrahydrofuran and 1 mL water were mixed with 79 mg (3.3 mmol) lithium hydroxide and stirred overnight at RT. The reaction mixture was acidified with 1M aqueous hydrochloric acid and evaporated down. The product was reacted without further purification.

Workup

  1. customevaporated down
  2. customThe product was reacted without further purification

Sources & evidence

ORD record
ord-c07db21c58be42b78949ab930e4c0d28
Source dataset
uspto-grants-2014_09
Patent number
US08829006B2

Reaction notes

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