Hydrochloric Acid → HCID 69212897, compound

HRID 746655Notes

Reaction equation

HRID 746655 reaction equation
[CH3:1][N:2]1[C:7](=[O:8])[C:6]2[C:9]([C:13]([O:15]C)=[O:14])=[C:10]([CH3:12])[S:11][C:5]=2[N:4]([CH:17]([CH3:19])[CH3:18])[C:3]1=[O:20].CO.[OH-].[Na+].Cl>C1COCC1>[CH3:1][N:2]1[C:7](=[O:8])[C:6]2[C:9]([C:13]([OH:15])=[O:14])=[C:10]([CH3:12])[S:11][C:5]=2[N:4]([CH:17]([CH3:18])[CH3:19])[C:3]1=[O:20]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 17974723491614-26-7

Product 1

HCID 69212897HCID 69212897, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of the product of step b) (3.81 g) in THF (50 ml) and methanol (5 ml) was added 1N NaOH (25.7 ml) and the mixture stirred under nitrogen for 18 hr. It was acidified with 2.5N HCl and extracted with DCM, the organic extracts washed with water, dried over anhydrous magnesium sulfate, filtered and evaporated under reduced pressure to give the sub-title compound as a solid (3.40 g)

Workup

  1. extractionextracted with DCM
  2. washthe organic extracts washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-c2b9f90ec9374a2dacf5dea18b7b4e5a
Source dataset
uspto-grants-2008_07
Patent number
US07393854B2

Reaction notes

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