Potassium Iodide → HCID 69301372, compound

HRID 747075Notes

Reaction equation

HRID 747075 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)=[CH:4][C:3]=1[C:15]#[N:16].Br[CH2:18][CH2:19][O:20][CH3:21].[I-].[K+].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]([O:14][CH2:18][CH2:19][O:20][CH3:21])=[CH:12][CH:13]=2)=[CH:4][C:3]=1[C:15]#[N:16]

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 809722-Bromoethyl methyl etherHCID 22890902HCID 22890902, compound

Product 1

HCID 69301372HCID 69301372, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

A mixture of 4-fluoro-4′-hydroxy-1,1′-biphenyl-3-carbonitrile (0.50 g, 2.35×10−3 mol), 1-bromo-2-methoxyethane (0.33 g, 2.35×10−3 mol), potassium iodide (0.04 g, 2.35×10−4 mol) and potassium carbonate (1.30 g, 9.40×10−3 mol) in butanone (20 cm3) was reacted, worked up and purified as described for compound 3 in Example 2. Yield 0.26 g (40%), GC purity (100%).

Workup

  1. customwas reacted
  2. custompurified

Sources & evidence

ORD record
ord-f7cc0ad7a7bd4804bc118b652a6d4dec
Source dataset
uspto-grants-2008_07
Patent number
US07396487B2

Reaction notes

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