1-Phenylpiperazine → [6-(4-Phenyl-piperazin-1-yl)-pyrimidin-4-yl]-quinolin-7-yl-amine

HRID 747138Notes

Reaction equation

HRID 747138 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:18]=[C:17]3[C:12]([CH:13]=[CH:14][CH:15]=[N:16]3)=[CH:11][CH:10]=2)[CH:3]=1.[C:19]1([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[C:19]1([N:25]2[CH2:30][CH2:29][N:28]([C:2]3[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]4[CH:18]=[C:17]5[C:12]([CH:13]=[CH:14][CH:15]=[N:16]5)=[CH:11][CH:10]=4)[CH:3]=3)[CH2:27][CH2:26]2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

5

Reactant 3

HCID 70961-PhenylpiperazineHCID 11430Potassium CarbonateHCID 22135502N-(6-chloro-4-pyrimidinyl)-7-Quinolinamine

Product 1

HCID 22135548[6-(4-Phenyl-piperazin-1-yl)-pyrimidin-4-yl]-quinolin-7-yl-amine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This compound could be prepared from (6-chloro-pyrimidin-4-yl)-quinolin-7-yl-amine and 1-phenyl-piperazine in the presence of K2CO3 and DMF.

Sources & evidence

ORD record
ord-1c1cca9551ab4ef28800872f71cb1d89
Source dataset
uspto-grants-2008_07
Patent number
US07396831B2

Reaction notes

Loading…