反应详情

To 6 g of N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]phenyl}-3,4-dimethoxybenzenesulfonamide dissolved in 50 ml of DMF at 0° C. is added portionwise 0.674 g of sodium hydride. After 1 hour at 0° C., 1.4 ml of ethyl 2-bromoacetate are introduced and the mixture is left for 18 hours at room temperature. The reaction medium is taken up in ethyl acetate and washed with water. The organic phase is dried over anhydrous sodium sulfate and concentrated. The residue is chromatographed on a column of silica gel, eluting with dichloromethane to give 1.3 g of the expected product.

1. waitthe mixture is left for 18 hours at room temperature
2. washwashed with water
3. dry with materialThe organic phase is dried over anhydrous sodium sulfate
4. concentrationconcentrated
5. customThe residue is chromatographed on a column of silica gel
6. washeluting with dichloromethane