Benzenesulfonyl chloride → HCID 131726960, compound

HRID 747676Notes

Reaction equation

HRID 747676 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:19]=[CH:20][CH:21]=1)[O:6][CH2:7][CH2:8][NH:9][C:10]([CH2:12][CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)=[O:11])#[N:2].C(N(CC)CC)C.[C:29]1([S:35](Cl)(=[O:37])=[O:36])[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1.C(OCC)(=O)C>CN(C)C=O>[C:29]1([S:35]([N:16]2[CH2:15][CH2:14][CH:13]([CH2:12][C:10]([NH:9][CH2:8][CH2:7][O:6][C:5]3[CH:19]=[CH:20][CH:21]=[C:3]([C:1]#[N:2])[CH:4]=3)=[O:11])[CH2:18][CH2:17]2)(=[O:37])=[O:36])[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1

Participants

6

Reactant 4

HCID 7369Benzenesulfonyl chlorideHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 131726959HCID 131726959, compound

Product 1

HCID 131726960HCID 131726960, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

430 mg (1.58 mmol) of N-[2-(3-cyanophenoxy)ethyl]piperidine-4-carboxyamide was dissolved in 10 ml of dimethylformamide. 0.2 ml (1.43 mmol) of triethylamine and 253 mg (1.43 mmol) of benzenesulfonyl chloride were added to the solution at 0° C., and they were stirred for 13 hours. After the treatment with ethyl acetate as the extractant in an ordinary manner, the title compound was obtained.

Sources & evidence

ORD record
ord-44d534053ba44da7a1431b383b687d68
Source dataset
uspto-grants-2008_07
Patent number
US07396844B1

Reaction notes

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