反应详情

4.57 g (31 mmol) of 4-chloropyridine and 5.03 g (31 mmol) of ethyl 4-aminobenzoate were dissolved in 100 ml of xylene. 12.7 ml (92 mmol) of triethylamine was added to the obtained solution and the resultant mixture was heated under reflux for 50 hours. The solvent was evaporated, and the residue was diluted with water. After the extraction with dichloromethane followed by washing with saturated Aqueous NaCl solution and drying over anhydrous magnesium sulfate, the solvent was evaporated and the residue was purified by the silica gel column chromatography to obtain the title compound.

1. temperatureunder reflux for 50 hours
2. customThe solvent was evaporated
3. additionthe residue was diluted with water
4. extractionAfter the extraction with dichloromethane
5. washby washing with saturated Aqueous NaCl solution
6. dry with materialdrying over anhydrous magnesium sulfate
7. customthe solvent was evaporated
8. customthe residue was purified by the silica gel column chromatography