Ethyl Acetate → HCID 54463448, compound

HRID 747746Notes

Reaction equation

HRID 747746 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][CH2:13][O:14][C:15]2[CH:16]=[C:17]([CH:20]=[CH:21][CH:22]=2)[C:18]#[N:19])(=[O:10])=[O:9])=[CH:4][CH:3]=1.C(OCC)(=O)C.[CH3:29][N:30]1CCCC1=O>[Cu+]>[C:29]([C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][CH2:13][O:14][C:15]2[CH:16]=[C:17]([CH:20]=[CH:21][CH:22]=2)[C:18]#[N:19])(=[O:10])=[O:9])=[CH:4][CH:3]=1)#[N:30]

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 13387N-methyl-2-pyrrolidoneHCID 53980250HCID 53980250, compound

Product 1

HCID 54463448HCID 54463448, compound

Reagents, catalysts & solvents 1

HCID 104815Copper(1+)Catalyst

Conditions

Temperature
140 °C

Procedure

300 mg (0.84 mmol) of 3-[2-(4-bromobenzenesulfonylamino)ethoxy]benzonitrile was dissolved in 1 ml of N-methylpyrrolidone. 76 mg (0.84 mmol) of copper (I) cyamide was added to the solution, and they were stirred at 140° C. overnight. The crude product was obtained by the treatment with ethyl acetate as the extractant in an ordinary manner. After the silica gel column chromatography, the title compound was obtained.

Sources & evidence

ORD record
ord-e74e2d9a73c04a328a51d079d74c9758
Source dataset
uspto-grants-2008_07
Patent number
US07396844B1

Reaction notes

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