反应详情

15.3 g (39.5 mmol) of t-butyl [2-(5-cyano-2-iodophenoxy)ethyl]carbamate, 9.05 g (63.2 mmol) of methyl 2-acetamidoacrylate, 11 ml (79 mmol) of triethylamine, 1.3 g of palladium (II) acetate and 7.30 g of tris(2-methylphenyl)phosphine were stirred in 150 ml of acetonitrile overnight. The solvent was distilled off, and the residue was treated by the silica gel chromatography (ethyl acetate/hexane) to obtain the crude product, which was washed with hexane and a mixed solvent of hexane/ethyl acetate, and then vacuum-dried to obtain the title compound.

1. distillationThe solvent was distilled off
2. additionthe residue was treated by the silica gel chromatography (ethyl acetate/hexane)
3. customto obtain the crude product, which
4. washwas washed with hexane
5. dry with materiala mixed solvent of hexane/ethyl acetate, and then vacuum-dried