Nitrogen → HCID 66846604, compound

To the ethyl propynoate (Aldrich, 3.96 g, 40 mmol) in THF (200 mL) in a 3-neck, 3-L round bottom flask equipped with an addition funnel, internal thermometer, and N2 inlet at 0° C. was added trifluoroacetic acid (TFA) (Aldrich, 0.3 mL, 4 mmol). Benzyl(methoxymethyl)trimethylsilylmethylamine (Aldrich, 23.7 g, 100 mmol) in 50 mL THF was added dropwise via addition funnel over 30 minutes with the reaction temperature being maintained below 5° C. After the addition was complete, the mixture was allowed to warm slowly to ambient temperature and then was stirred for 10 h. The mixture was concentrated and the residue was dissolved in 500 mL EtOAc. It was washed with 2×50 mL saturated NaHCO3 and 25 mL brine, dried over Na2SO4, and concentrated under reduced pressure. The residue was purified by column chromatography (SiO2, 50% hexanes-EtOAc) to give 14.5 g of the title compound (36.6 mmol, 91% yield). MS (DCl/NH3) m/z 365 (M+H)+.

1. temperaturebeing maintained below 5° C
2. additionAfter the addition
3. concentrationThe mixture was concentrated
4. dissolutionthe residue was dissolved in 500 mL EtOAc
5. washIt was washed with 2×50 mL saturated NaHCO3 and 25 mL brine
6. dry with materialdried over Na2SO4
7. concentrationconcentrated under reduced pressure
8. customThe residue was purified by column chromatography (SiO2, 50% hexanes-EtOAc)

ORD record

ord-ed20116c09bc49f0ba8d887bcad7aaa9

Source dataset

uspto-grants-2008_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07399765B2