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HRID74846

反应详情

EQUATION

反应方程式

HRID 74846 的结构方程式

REACTANTS

反应物

2
结构：[N-]=[N+]=[N-].[Na+]
HCID33557

未命名化合物

结构：CC(=O)OC[C@H]1O[C@H](Br)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1O[C@H]1O[C@H](COC(C)=O)[C@@H](O[C@H]2O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O
HCID13055893

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)OC[C@H]1O[C@@H](N=[N+]=[N-])[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1O[C@H]1O[C@H](COC(C)=O)[C@@H](O[C@H]2O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O
HCID11205331

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

3
结构：CCCC[N+](CCCC)(CCCC)CCCC.[Br-]
催化剂HCID74236

未命名化合物

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

2 次

结构：O=C([O-])O.[Na+]
溶剂HCID516892

Sodium Bicarbonate

CHNaO3

PROCEDURE

实验过程

The bromide 72 (˜200 mg) was taken up in a mixture of EtOAc (5 mL) and NaHCO3 (sat.) (5 mL). NaN3 (500 mg) was added, followed by Bu4NBr (cat.). The mixture was stirred vigorously overnight at r.t. The solution was diluted with EtOAc and washed with NaHCO3(sat.) (×2) and brine (×1), before being dried (Na2SO4) and the solvent evaporated to yield the azide 73 as white solid (198.9 mg, 100%, two steps) which was reacted on without further purification or characterisation.

WORKUP

后处理

  1. washwashed with NaHCO3(sat.) (×2) and brine (×1)
  2. dry with materialbefore being dried (Na2SO4)
  3. customthe solvent evaporated