反应详情

Into 10 mL of THF was dissolved 135 mg of methyl 4-amino-5-methanesulfonyl-2-methylbenzoate, followed by addition of 22 mg of sodium hydride (oily, 60%) at room temperature. After 20 minutes of stirring at the same temperature, 130 mg of 5-chloro-2-chlorosulfonyl-3-methylbenzo[b]thiophene was added at 0° C., followed by 1 hour of stirring at room temperature and 5 hours of heating under refluxing. Further, 1 mL of DMF, 22 mg of sodium hydride (oily, 60%) and 50 mg of 5-chloro-2-chlorosulfonyl-3-methylbenzo[b]thiophene were added and the mixture was heated under refluxing for 2.5 hours. After-confirmation of disappearance of the starting material, the reaction was terminated by adding saturated aqueous ammonium chloride solution at 0° C., followed by extraction with ethyl acetate. The organic layer was washed with saturated brine and then dried over anhydrous sodium sulfate. The solvent was removed by evaporation and the residue was purified by silica gel column chromatography (ethyl acetate/hexane=3/2) to obtain 102 mg of the title compound as colorless powder.

1. additionwas added at 0° C.
2. temperatureof heating
3. temperatureunder refluxing
4. temperaturethe mixture was heated
5. temperatureunder refluxing for 2.5 hours
6. customAfter-confirmation of disappearance of the starting material, the reaction was terminated
7. additionby adding saturated aqueous ammonium chloride solution at 0° C.
8. extractionfollowed by extraction with ethyl acetate
9. washThe organic layer was washed with saturated brine
10. dry with materialdried over anhydrous sodium sulfate
11. customThe solvent was removed by evaporation
12. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane=3/2)