Sodium hydride → HCID 22235059, compound

HRID 749530Notes

Reaction equation

HRID 749530 reaction equation
[F:1][C:2]1[CH:13]=[C:12]([F:14])[CH:11]=[C:10]([F:15])[C:3]=1[CH2:4][CH:5]([C:8]#[N:9])[C:6]#[N:7].[H-].[Na+].Br[CH2:19][CH2:20][C:21]([F:24])([F:23])[F:22]>CN(C)C=O>[F:1][C:2]1[CH:13]=[C:12]([F:14])[CH:11]=[C:10]([F:15])[C:3]=1[CH2:4][C:5]([CH2:19][CH2:20][C:21]([F:24])([F:23])[F:22])([C:8]#[N:9])[C:6]#[N:7]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 27251143-Bromo-1,1,1-trifluoropropaneHCID 22235063HCID 22235063, compound

Product 1

HCID 22235059HCID 22235059, compoundYield 10%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using 0.50 g of (2,4,6-trifluorobenzyl)malononitrile, 10 ml of N,N-dimethylformamide, 0.11 g of sodium hydride (60% in oil), and 0.46 g of 1-bromo-3,3,3-trifluoropropane, and according to the process described in the Production Example 1, there was obtained 0.07 g of 2-(2,4,6-trifluorobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (17)).

Sources & evidence

ORD record
ord-815e43ca22d044579fcb47fd4392a62b
Source dataset
uspto-grants-2008_07
Patent number
US07402691B2

Reaction notes

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