Sodium hydride → HCID 22234997, compound

HRID 749540Notes

Reaction equation

HRID 749540 reaction equation
[CH:1]([C:3]1[CH:10]=[CH:9][C:6]([CH2:7]Cl)=[CH:5][CH:4]=1)=[CH2:2].[H-].[Na+].[F:13][C:14]([F:23])([F:22])[CH2:15][CH2:16][CH:17]([C:20]#[N:21])[C:18]#[N:19]>CN(C)C=O>[F:13][C:14]([F:22])([F:23])[CH2:15][CH2:16][C:17]([CH2:7][C:6]1[CH:9]=[CH:10][C:3]([CH:1]=[CH2:2])=[CH:4][CH:5]=1)([C:20]#[N:21])[C:18]#[N:19]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 74126p-Vinylbenzyl chlorideHCID 221857612-(3,3,3-Trifluoropropyl)malononitrile

Product 1

HCID 22234997HCID 22234997, compoundYield 65.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using 0.15 g of (4-vinylbenzyl)chloride, 3 ml of N,N-dimethylformamide, 0.05 g of sodium hydride (60% in oil) and 0.17 g of (3,3,3-trifluoropropyl)malononitrile, and according to the process described in the Production Example 27, there was obtained 0.18 g of 2-(3,3,3-trifluoropropyl)-2-(4-vinylbenzyl)malononitrile (the present compound (27)).

Sources & evidence

ORD record
ord-818545936bd745fcac303597c7fbbe9e
Source dataset
uspto-grants-2008_07
Patent number
US07402691B2

Reaction notes

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