Sodium hydride → HCID 22235041, compound

HRID 749556Notes

Reaction equation

HRID 749556 reaction equation
CS(O[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[C:9]([CH3:16])[CH:8]=1)(=O)=O.[H-].[Na+].[F:19][C:20]([F:29])([F:28])[CH2:21][CH2:22][CH:23]([C:26]#[N:27])[C:24]#[N:25]>CN(C)C=O>[CH3:16][C:9]1[CH:8]=[C:7]([CH:12]=[CH:11][C:10]=1[N+:13]([O-:15])=[O:14])[CH2:6][C:23]([CH2:22][CH2:21][C:20]([F:19])([F:28])[F:29])([C:24]#[N:25])[C:26]#[N:27]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 221857612-(3,3,3-Trifluoropropyl)malononitrileHCID 22235020HCID 22235020, compound

Product 1

HCID 22235041HCID 22235041, compoundYield 88.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using 0.49 g of 3-metyl-4-nitrobenzyl methanesulfonate, 5 ml of N,N-dimethylformamide, 0.10 g of sodium hydride (60% in oil), and 0.3 g of (3,3,3-trifluoropropyl)malononitrile, and according to the process described in the Production Example 26, there was obtained 0.51 g of 2-(3-methyl-4-nitrobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (45)).

Sources & evidence

ORD record
ord-546fa157cee34aabb5628ffb336390ed
Source dataset
uspto-grants-2008_07
Patent number
US07402691B2

Reaction notes

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