Lithium Hydroxide → HCID 67285599, compound

HRID 74963Notes

Reaction equation

HRID 74963 reaction equation
CN(C(ON1N=[N:16][C:11]2[CH:12]=[CH:13][CH:14]=[N:15][C:10]1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.ClC1C=C2C(B3OC(C)(C)C(C)(C)[O:36]3)=CN(S(C3C=CC(C)=CC=3)(=O)=O)C2=NC=1.[Cl:54][C:55]1[CH:56]=[C:57]2[C:63]([C:64]3[N:69]=[C:68](S(C)=O)[C:67]([F:73])=[CH:66][N:65]=3)=[CH:62][N:61](S(C3C=CC(C)=CC=3)(=O)=O)[C:58]2=[N:59][CH:60]=1.[Li+].[OH-:85]>C(Cl)Cl.CN(C=O)C.N1C=CC=CC=1>[Cl:54][C:55]1[CH:56]=[C:57]2[C:63]([C:64]3[N:69]=[C:68]([NH:16][CH:11]4[CH2:12][O:85][CH2:13][CH2:14][NH:15][C:10]4=[O:36])[C:67]([F:73])=[CH:66][N:65]=3)=[CH:62][NH:61][C:58]2=[N:59][CH:60]=1

Participants

8

Reactant 4

HCID 3939Lithium HydroxideHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)2×HCID 575977475-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridineHCID 672853215-Chloro-3-(5-fluoro-4-methylsulfinyl-pyrimidin-2-yl)-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine

Product 1

HCID 67285599HCID 67285599, compound

Reagents, catalysts & solvents 3

HCID 1049PyridineSolventHCID 6228DimethylformamideSolvent3×HCID 6344DichloromethaneSolvent

Procedure

Amine, HATU, DMF; (b) BOC2O, NH4CO3H, pyridine, DMF; (c) i: Amine, HATU, DMF; then ii: 1N LiOH.

Sources & evidence

ORD record
ord-64c83f338c5745f887fbf6ee9e45da00
Source dataset
uspto-grants-2014_09
Patent number
US08829007B2

Reaction notes

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