1,2-Epoxybutane → HCID 23060831, compound

HRID 750123Notes

Reaction equation

HRID 750123 reaction equation
[CH3:1][S:2]([C:5]1[CH:12]=[CH:11][C:8]([CH2:9][NH2:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[O:13]1[CH:15]([CH2:16][CH3:17])[CH2:14]1>CC(O)C>[CH3:1][S:2]([C:5]1[CH:12]=[CH:11][C:8]([CH2:9][NH:10][CH2:14][CH:15]([OH:13])[CH2:16][CH3:17])=[CH:7][CH:6]=1)(=[O:3])=[O:4]

Participants

4

Reactant 2

HCID 78341,2-EpoxybutaneHCID 574214-Methylsulfonylbenzylamine

Product 1

HCID 23060831HCID 23060831, compoundYield 43.3%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A solution (6 ml) of 4-methanesulfonylbenzylamine (3.0 g) and 1,2-epoxybutane (1.1 g) in 2-propanol was heated under reflux for 12 hrs. The reaction mixture was concentrated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (ethyl acetate-ethyl acetate:methanol=10:1) to give the title compound (1.7 g).

Workup

  1. temperatureunder reflux for 12 hrs
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customthe obtained residue was purified by silica gel column chromatography (ethyl acetate-ethyl acetate:methanol=10:1)

Sources & evidence

ORD record
ord-5b638485fb8c426dab6670d2699730d5
Source dataset
uspto-grants-2008_07
Patent number
US07402595B2

Reaction notes

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