huagongshe.com
HRID75053

反应详情

EQUATION

反应方程式

HRID 75053 的结构方程式

REACTANTS

反应物

7
结构：O=P([O-])([O-])[O-].[K+].[K+].[K+]
HCID62657

Tripotassium phosphate

K3O4P

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

2 次

结构：[BH4-].[Na+]
HCID4311764

Sodium borohydride (Na(BH4))

H4BNa

结构：CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1
HCID11155794

2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl

C33H49P

结构：Cc1ccc(S(=O)(=O)n2cc(B3OC(C)(C)C(C)(C)O3)c3cc(Cl)cnc32)cc1
HCID57597747

5-Chloro-1-(4-methylbenzene-1-sulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine

C20H22BClN2O4S

2 次

结构：Cc1ccc(S(=O)(=O)n2cc(-c3ncc(F)c(S(C)=O)n3)c3cc(Cl)cnc32)cc1
HCID67285321

未命名化合物

结构：O=C(N[C@@H]1CCC[C@H](Nc2nc(Cl)ncc2F)C1)N1CC[C@@H](F)C1
HCID86719751

未命名化合物

PRODUCTS

生成物

1
结构：Fc1cnc2[nH]cc(-c3ncc(F)c(N[C@H]4CCC[C@@H](Nc5cnccn5)C4)n3)c2c1
HCID68008579

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

6
结构：O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Pd].[Pd]
催化剂HCID9811564

Bis(dibenzylideneacetone)palladium

C51H42O3Pd2

结构：c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1
催化剂HCID178418397

未命名化合物

结构：CO
溶剂HCID887

Methanol

CH4O

结构：O
溶剂HCID962

Water

H2O

结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

NaBH4, MeOH; (b) 5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine, 2-Me-THF, water, K3PO4, Pd(PPh3)4, XPhos, Tris(dibenzylideneacetone)dipalladium, reflux; (c) bis(2,5-dioxopyrrolidin-1-yl) carbonate, iPr2NEt, CH3CN; (d) (3R)-3-fluoropyrrolidine, iPr2NEt, CH3CN (e) 2N LiOH, THF.