Triethylamine → HCID 86591703, compound

HRID 750918Notes

Reaction equation

HRID 750918 reaction equation
[CH2:1]([N:3](CC)CC)[CH3:2].[Br-].[Li+].C(OP(CC#N)(=O)OCC)C.O=[C:22]1[CH2:27][CH2:26][N:25]([C:28]2[CH:33]=[CH:32][C:31]([N:34]3[CH2:38][C@@H:37]([CH2:39][N:40]=[N+:41]=[N-:42])[O:36][C:35]3=[O:43])=[CH:30][CH:29]=2)[CH2:24][CH2:23]1>O1CCCC1>[C:1]([CH:2]=[C:22]1[CH2:27][CH2:26][N:25]([C:28]2[CH:33]=[CH:32][C:31]([N:34]3[CH2:38][C@@H:37]([CH2:39][N:40]=[N+:41]=[N-:42])[O:36][C:35]3=[O:43])=[CH:30][CH:29]=2)[CH2:24][CH2:23]1)#[N:3]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 75676Diethyl (cyanomethyl)phosphonateHCID 82050Lithium BromideHCID 90842040HCID 90842040, compound

Product 1

HCID 86591703HCID 86591703, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The mixure of triethylamine (13.8 mmol), lithium bromide (8.2 mmol) and diethylcyanomethylphosphonate (7.2 mmol) in 25 ml tetrahydrofuran was stirred for 20 minutes at room temperature. To the suspension, (S)-{3-[4-(4-oxo-piperidin-1-yl)-phenyl]-2-oxo-oxazolodin-5-ylmethyl}-azide (6.9 mmol) was added. The reaction mixture stirred for 5 hours.

Sources & evidence

ORD record
ord-243d8dbc2fac4ba997730e12db166c4c
Source dataset
uspto-grants-2008_07
Patent number
US07405228B2

Reaction notes

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