Hydrochloric Acid → HCID 11440932, compound

HRID 751416Notes

Reaction equation

[Cl:1][C:2]1[N:3]([C:13]2[CH:14]=[C:15]([NH:19][C:20](=[O:22])[CH3:21])[CH:16]=[CH:17][CH:18]=2)[C:4]2[C:9]([C:10]=1[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=2.[NH:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1.Cl>>[ClH:1].[CH:11]([C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]([C:13]2[CH:14]=[C:15]([NH:19][C:20](=[O:22])[CH3:21])[CH:16]=[CH:17][CH:18]=2)[C:2]=1[N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)=[O:12]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 4837Piperazine

HCID 86035950HCID 86035950, compound

Product 1

HCID 11440932HCID 11440932, compoundYield 37%

Procedure

N-[3-(2-chloro-3-formyl-indol-1-yl)phenyl]-acetamide is reacted with piperazine as described in Step 2 of Example 29 and subsequently treated with hydrochloric acid as described in Example 44 to afford N-{3-[3-Formyl-2-(piperazin-1-yl)-indol-1-yl]phenyl}-acetamide hydrochloride (37% yield) as a cream solid. ESI/MS 363 (M+H); RT 2.2 min.

Sources & evidence

ORD record: ord-560af813e2604dcfb6582c64f842f9fd
Source dataset: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07405300B2

Reaction notes

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