Hydrogen Peroxide → HCID 69268667, compound

HRID 751507Notes

Reaction equation

HRID 751507 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][C:11]#[N:12])=[CH:2]1.[C:13](=[O:16])([O-])[O-].[K+].[K+].OO.[OH2:21]>CS(C)=O>[OH:16][CH2:13][CH:3]1[CH2:4][CH2:5][N:1]2[C:9]3[C:4]([C:3]([CH2:10][C:11]([NH2:12])=[O:21])=[C:2]2[CH2:2]1)=[CH:5][CH:6]=[CH:7][CH:8]=3

Participants

6

Reactant 4

HCID 784Hydrogen PeroxideHCID 962WaterHCID 11430Potassium CarbonateHCID 351795Indole-3-acetonitrile

Product 1

HCID 69268667HCID 69268667, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Dissolve (1H-indol-3-yl)acetonitrile (3.40 mmol) in dry dimethyl sulfoxide (3.0 mL), cool in an ice bath, combine with anhydrous potassium carbonate (0.200 g) and 30% hydrogen peroxide (0.6 mL), keeping the reaction temperature below 20° C. Warm to room temperature, add water (10 mL) and filter the resulting solid, dry under vacuum.

Workup

  1. temperaturecool in an ice bath
  2. customthe reaction temperature below 20° C
  3. filtrationfilter the resulting solid
  4. customdry under vacuum

Sources & evidence

ORD record
ord-4f065e5a1ccc4a4592e36fe473d7f53e
Source dataset
uspto-grants-2008_07
Patent number
US07405305B2

Reaction notes

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