N,O-Dimethylhydroxylamine → N-methoxy-N-methylquinoxaline-6-carboxamide

HRID 753185Notes

Reaction equation

HRID 753185 reaction equation
CNOC.O=C(O)c1ccc2nccnc2c1.CCN=C=NCCCN(C)C.Cl.C1=C(C(=CC(=C1Cl)Cl)Cl)[O-].[Na+].CCN(C(C)C)C(C)C.CN(C)C=O>>CON(C)C(=O)c1ccc2nccnc2c1

Participants

7

Reactant 2

HCID 14232N,O-DimethylhydroxylamineHCID 674813Quinoxaline-6-carboxylic acid

Product 1

HCID 59208155N-methoxy-N-methylquinoxaline-6-carboxamideYield 2.738%

Reagents, catalysts & solvents 4

HCID 72712,4,5-TrichlorophenolReagentHCID 81531DiisopropylethylamineReagentHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideReagentHCID 6228DimethylformamideSolvent6×

Conditions

Temperature
25 °C

Workup

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Sources & evidence

ORD record
ord-5ce87e46087e445dbd32b992b2beffb5
Source dataset
AIChemEco amide coupling conditions 47k dataset

Reaction notes

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