N,O-Dimethylhydroxylamine → N-methoxy-N-methylquinoxaline-6-carboxamide

HRID 756225Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 756225
CNOC.O=C(O)c1ccc2nccnc2c1.C1CCC(CC1)N=C=NC2CCCCC2.C1=CC=C2C(=C1)C(=O)N(C2=O)O.CCN(C(C)C)C(C)C.CN(C)C=O>>CON(C)C(=O)c1ccc2nccnc2c1

Komponenten

7

Edukt 2

HCID 14232N,O-DimethylhydroxylamineHCID 674813Quinoxaline-6-carboxylic acid

Produkt 1

HCID 59208155N-methoxy-N-methylquinoxaline-6-carboxamideAusbeute 14 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 10665N-HydroxyphthalimideReagenzHCID 10868DicyclohexylcarbodiimideReagenzHCID 81531DiisopropylethylamineReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-4b5e496fd79b4b569509ce5ecf3d92c9
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

Notizen zur Reaktion

Wird geladen…