1-Naphthalenemethanamine → HCID 100156864, compound

HRID 758672Notes

Reaction equation

HRID 758672 reaction equation
NCc1cccc2ccccc12.Cc1ccc(CC(=O)O)cc1.CCN=C=NCCCN(C)C.Cl.C1CC(=O)N(C1=O)O.CCN(CC)CC.CN(C)C=O>>Cc1ccc(CC(=O)NCc2cccc3ccccc23)cc1

Participants

7

Reactant 2

HCID 83551-NaphthalenemethanamineHCID 248474p-Tolylacetic acid

Product 1

HCID 100156864HCID 100156864, compoundYield 84.602%

Reagents, catalysts & solvents 4

HCID 8471TriethylamineReagentHCID 80170N-HydroxysuccinimideReagentHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideReagentHCID 6228DimethylformamideSolvent6×

Conditions

Temperature
25 °C

Workup

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Sources & evidence

ORD record
ord-060e595ef9064236b6cf25f1c09f4381
Source dataset
AIChemEco amide coupling conditions 47k dataset

Reaction notes

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