反应详情

A mixture of 1,4-diaminobenzene (4 g, 37 mmol), ethyl isocyanate (1 mL, 12.6 mmol) and potassium carbonate (8.72 g, 63 mmol) in THF (20 mL) was stirred at room temperature overnight. The reaction mixture was partitioned in 1N HCl solution (80 mL) and ethyl acetate (80 mL). The aqueous layer was extracted with ethyl acetate (4×80 mL). The combined organic layers was dried, evaporated, recrystallized from MeOH/CH2Cl2/hexanes to give 4-(ethylaminocarbonylamino)aniline (1.4 g, 62%) as a beige solid.

1. customThe reaction mixture was partitioned in 1N HCl solution (80 mL)
2. extractionThe aqueous layer was extracted with ethyl acetate (4×80 mL)
3. customThe combined organic layers was dried
4. customevaporated
5. customrecrystallized from MeOH/CH2Cl2/hexanes