反应详情

To a solution of [(4-fluoro-phenyl)-methyl-amino]-phenyl-acetic acid ethyl ester (I70) (0.59 g, 2.05 mmol) in THF (10 mL) and water (10 mL), is added lithium hydroxide hydrate (0.26 g, 6.14 mmol). The reaction is stirred at RT for 3.5 hours and then at 70° C. for 24 hours. 3N HCl is added till pH is about 1 and the mixture is evaporated. Water (15 mL) is added and the residue is triturated obtaining a pale brown suspension that is filtered on a buckner funnel, washed with water and then with acetonitrile. The solid is dried under vacuum at 40° C. overnight to obtain intermediate I119 as a pale brown powder (0.44 g, 72% yield).

1. waitat 70° C. for 24 hours
2. customthe mixture is evaporated
3. additionWater (15 mL) is added
4. customthe residue is triturated
5. customobtaining a pale brown suspension that
6. filtrationis filtered on a buckner funnel
7. washwashed with water
8. customThe solid is dried under vacuum at 40° C. overnight