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HRID77417

反应详情

EQUATION

反应方程式

HRID 77417 的结构方程式

REACTANTS

反应物

5
结构：CCN=C=NCCCN(C)C
HCID15908

1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide

C8H17N3

结构：On1nnc2ccccc21
HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：O=C(O)c1ccc(C2CCCCC2)cc1
HCID88337

4-Cyclohexylbenzoic acid

C13H16O2

结构：COc1ccc(CN(Cc2ccc3c(c2)CC[C@H](CN)C3)CC2CCOCC2)cc1
HCID66663221

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(CN(Cc2ccc3c(c2)CC[C@H](N(C)C(=O)c2ccc(C4CCCCC4)cc2)C3)CC2CCOCC2)cc1
HCID66663414

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

A mixture of 4-cyclohexylbenzoic acid (45 mg), DMF (1 ml), 1-ethyl-3-(3-dimethylamino-propyl)carbodiimide (hydrochloride, 45 mg) and 1-hydroxybenzotriazole (32 mg) was admixed after 5 minutes with diisopropylethylamine (30 mg) and ((S)-6-{[(4-methoxybenzyl)-(tetrahydropyran-4-ylmethyl)amino]methyl}-1,2,3,4-tetrahydronaphthalen-2-yl)methylamine (80 mg). Volatile fractions were removed after 12 hours. The residue was purified by preparative HPLC. The product was thus obtained with the molecular weight of 594.84 (C28H38N2O3); MS (ESI) 595 (M+H+).

WORKUP

后处理

  1. customVolatile fractions were removed after 12 hours
  2. customThe residue was purified by preparative HPLC
  3. customThe product was thus obtained with the molecular weight of 594.84 (C28H38N2O3)