4-Methylmorpholine → HCID 178520194, compound

HRID 77631Notes

Reaction equation

HRID 77631 reaction equation
Cl.[N:2]1([C:8]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)=[O:9])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.O[N:20]1[C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=2[N:22]=[N:21]1.CN1CC[O:33][CH2:32][CH2:31]1.Cl.CN(C)CCCN=C=N>CN(C=O)C>[NH:20]1[C:24]2[CH:25]=[CH:26][C:27]([CH2:31][C:32]([N:5]3[CH2:6][CH2:7][N:2]([C:8]([O:10][CH2:11][C:12]4[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=4)=[O:9])[CH2:3][CH2:4]3)=[O:33])=[CH:28][C:23]=2[N:22]=[N:21]1

Participants

6

Reactant 4

HCID 79724-MethylmorpholineHCID 757711-HydroxybenzotriazoleHCID 21899179Dimethylaminopropyl carbodiimide hydrochlorideHCID 666643964-Chlorobenzyl piperazine-1-carboxylate hydrochloride

Product 1

HCID 178520194HCID 178520194, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

7.3 220 mg (1.24 mmol) of 23, 362 mg (1.24 mmol) of 4-chlorobenzyl piperazine-1-carboxylate hydrochloride, 168 mg (1.24 mmol) of 1-hydroxybenzotriazole (HOBt), 143 mg (1.24 mmol) of N-methylmorpholine and 238 mg (1.24 mmol) of 3-dimethylaminopropylcarbodiimide hydrochloride (DAPECI) are stirred at RT for 48 h in 10 ml of DMF.

Sources & evidence

ORD record
ord-9c0c5010c8dc468cac1b68cd317e6b5d
Source dataset
uspto-grants-2014_09
Patent number
US08841324B2

Reaction notes

Loading…