反应详情

温度

80 °C

To an N,N-dimethylformamide (30.0 mL) solution of 2-fluorophenol (5.43 g, 48.4 mmol) and 4-fluorobenzaldehyde (3.00 g, 24.2 mmol) was added potassium carbonate (10.1 g, 72.5 mmol) under nitrogen atmosphere, which was stirred for 16 hours at 80° C. Water was added to the reaction solution at room temperature, which was then extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride, and the solvent was evaporated under a reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:heptane=1:15→1:10) to obtain the title compound (5.20 g, 99.4%).

1. extractionwhich was then extracted with ethyl acetate
2. washThe organic layer was washed with saturated aqueous sodium chloride
3. customthe solvent was evaporated under a reduced pressure
4. customThe residue was purified by silica gel column chromatography (ethyl acetate:heptane=1:15→1:10)