Triethylamine → HCID 178513395, compound

HRID 78595Notes

Reaction equation

HRID 78595 reaction equation
[NH2:1][C:2]1[C:3]([C:9]#[N:10])=[N:4][C:5]([Br:8])=[CH:6][N:7]=1.Cl.[NH2:12][OH:13].C(N(CC)CC)C>CO>[NH2:1][C:2]1[C:3]([C:9](=[NH:10])[NH:12][OH:13])=[N:4][C:5]([Br:8])=[CH:6][N:7]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 443297Hydroxyamine hydrochlorideHCID 110526113-Amino-6-bromopyrazine-2-carbonitrile

Product 1

HCID 178513395HCID 178513395, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

A mixture of 3-amino-6-bromo-pyrazine-2-carbonitrile (1 g, 5.025 mmol) was dissolved in MeOH (20.00 mL) and cooled to 0° C. Hydroxylamine hydrochloride (349.2 mg, 5.025 mmol) and triethylamine (508.5 mg, 700.4 μL, 5.025 mmol) were added and the reaction allowed to warm to ambient temperature. After 2 hours the resultant precipitate was filtered off and dried (898 mg, 77% Yield). MS (ES+) 234.89

Workup

  1. temperatureto warm to ambient temperature
  2. filtrationAfter 2 hours the resultant precipitate was filtered off
  3. customdried (898 mg, 77% Yield)

Sources & evidence

ORD record
ord-cd496f633cdf4627964591ce8f645cbb
Source dataset
uspto-grants-2014_09
Patent number
US08841308B2

Reaction notes

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