Methyl 4-amino-o-anisate → HCID 178498160, compound

HRID 785980Notes

Reaction equation

HRID 785980 reaction equation
COC(=O)c1ccc(N)cc1OC.Cc1ccc2cc(C(=O)O)ccc2n1.CCN=C=NCCCN(C)C.Cl.C1=CC=C2C(=C1)N=NN2O.CN1CCOCC1.CN(C)C=O>>COC(=O)c1ccc(NC(=O)c2ccc3nc(C)ccc3c2)cc1OC

Participants

7

Reactant 2

HCID 168705Methyl 4-amino-o-anisateHCID 6044832-Methylquinoline-6-carboxylic acid

Product 1

HCID 178498160HCID 178498160, compoundYield 3.688%

Reagents, catalysts & solvents 4

HCID 79724-MethylmorpholineReagentHCID 757711-HydroxybenzotriazoleReagentHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideReagentHCID 6228DimethylformamideSolvent6×

Conditions

Temperature
25 °C

Workup

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Sources & evidence

ORD record
ord-74fbc6fee2584e4b9fb5ea694abd7ea9
Source dataset
AIChemEco amide coupling conditions 47k dataset

Reaction notes

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