反应详情

温度

120 °C

A solution of 3-(4-tert-butyl-N-methylbenzamido)benzenesulfonic acid (12 mg, 35 μmol), cyanuric chloride (7.0 mg, 40 μmol), and triethylamine (6.0 μL, 40 μmol) in acetone (0.5 mL) was sealed in a glass tube and heated in a microwave oven at 120° C. for 10 min. Concentrated ammonium hydroxide (150 μL) was added, and the reaction was stirred for 6 h. The reaction was filtered, and the filtrate was purified by preparative reverse phase HPLC using 10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA) to give 4-tert-butyl-N-methyl-N-(3-(aminosulfonyl)phenyl)benzamide. LC/MS: m/z 347.3 (M+H)+ at 2.86 min (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)).

1. filtrationThe reaction was filtered
2. customthe filtrate was purified by preparative reverse phase