反应详情

温度

80 °C

A mixture of N-(3-ethyl-1-((2-methoxy-6-methylpyridin-3-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide (50 mg, 0.11 mmol) and HCl (2 mL, 4M in dioxane) was heated at 80° C. in a sealed vial for 4 hours. The reaction mixture was diluted with ethyl acetate (20 mL) and water (5 mL). Saturated NaHCO3 aqueous solution was added to adjust pH=7. The solution was concentrated under reduced pressure to a solid residue. The residue was dissolved in DCM/MeOH and filtered to remove inorganic impurities. The solution was concentrated under reduced pressure to give the product (48 mg).

1. concentrationThe solution was concentrated under reduced pressure to a solid residue
2. dissolutionThe residue was dissolved in DCM/MeOH
3. filtrationfiltered
4. customto remove inorganic impurities
5. concentrationThe solution was concentrated under reduced pressure