Acetone → 1'-(2,2,2-Trifluoroethyl)-spiro[indoline-3,4'-piperidin]-2-one

HRID 799737Notes

Reaction equation

HRID 799737 reaction equation
[CH3:36][CH2:37][N:38]([CH2:39][CH3:40])[CH2:41][CH3:42].[CH3:43][C:44](=[O:45])[CH3:46].[F:23][C:24]([F:25])([F:26])[S:27]([O:28][CH2:29][C:30]([F:31])([F:32])[F:33])(=[O:34])=[O:35].[NH:1]1[CH2:2][CH2:3][C:4]2([C:5](=[O:13])[NH:6][c:7]3[cH:8][cH:9][cH:10][cH:11][c:12]32)[CH2:14][CH2:15]1.[OH:16][C:17](=[O:18])[C:19]([F:20])([F:21])[F:22]>>[N:1]1([CH2:17][C:19]([F:20])([F:21])[F:22])[CH2:2][CH2:3][C:4]2([C:5](=[O:13])[NH:6][c:7]3[cH:8][cH:9][cH:10][cH:11][c:12]32)[CH2:14][CH2:15]1

Participants

6

Reactant 5

HCID 180AcetoneHCID 6422Trifluoroacetic acidHCID 8471TriethylamineHCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonateHCID 18435788Spiro(indole-3,4'-piperidin)-2(1H)-one

Product 1

HCID 184493581'-(2,2,2-Trifluoroethyl)-spiro[indoline-3,4'-piperidin]-2-one

Sources & evidence

ORD record
ord-dbb80c38d9ab461ab86391abde64e823
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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