1,2-Dichloroethane → 3-(4-fluorophenyl)-N-[1-[3-(4-methylpiperazin-1-yl)phenyl]ethyl]prop-2-enamide

HRID 800731Notes

Reaction equation

HRID 800731 reaction equation
[CH2:29]([Cl:30])[CH2:31][Cl:32].[CH3:13][N:14]1[CH2:15][CH2:16][N:17]([c:20]2[cH:21][c:22]([CH:26]([CH3:27])[NH2:28])[cH:23][cH:24][cH:25]2)[CH2:18][CH2:19]1.[CH3:33][CH2:34][N:35]([CH2:36][CH3:37])[CH2:38][CH3:39].[CH3:40][N:41]([c:42]1[cH:43][cH:44][n:45][cH:46][cH:47]1)[CH3:48].[Cl:49][CH2:50][Cl:51].[F:1][c:2]1[cH:3][cH:4][c:5]([CH:6]=[CH:7][C:8](=[O:9])[OH:10])[cH:11][cH:12]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH:6]=[CH:7][C:8](=[O:10])[NH:28][CH:26]([c:22]2[cH:21][c:20]([N:17]3[CH2:16][CH2:15][N:14]([CH3:13])[CH2:19][CH2:18]3)[cH:25][cH:24][cH:23]2)[CH3:27])[cH:11][cH:12]1

Participants

7

Reactant 6

HCID 111,2-DichloroethaneHCID 6344DichloromethaneHCID 8471TriethylamineHCID 142844-(Dimethylamino)pyridineHCID 980703-(4-Fluorophenyl)-2-propenoic acidHCID 226054871-[3-(4-Methylpiperazin-1-yl)phenyl]ethanamine

Product 1

HCID 699171373-(4-fluorophenyl)-N-[1-[3-(4-methylpiperazin-1-yl)phenyl]ethyl]prop-2-enamide

Sources & evidence

ORD record
ord-f845eea87a6443ef8264ff5fdab58028
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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